MIDDELBEEK, HANS ALMER,KIRKELS, MONIQUE,BIEMANS, ROGIER
申请号：
NZ58638509
公开号：
NZ586385A
申请日:
2009.01.20
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
Disclosed is a method for lyophilising particles (30) comprising frozen liquid having a pharmaceutical compound contained therein. A heat conducting container (15, 15') having a bottom and side walls is filled with a bed (29) of the particles, the bed comprising multiple layers of the particles and having an aspect ratio (ratio of the width of the bed to its height) of not less than 1. A heat source (5a-c) is located above a top layer of the particles, the heat source having a surface directed to a top layer of the bed, the surface having an emissivity coefficient of at least 0.4. The particles filled in the container are subjected to a reduced pressure. At least the bottom of the container and the surface are heated to provide heat to the particles to support sublimation of the frozen liquid at the reduced pressure, and after the frozen liquid is sublimated, stopping the provision of heat to the particles. The invention also includes to a pharmaceutical pack comprising a container having contained therein at least one particle obtained via this method.
