This invention is something which offers the combined use medicine which is superior in the preventive of the thrombus embolism or curative effect, is the anti- blood platelet medicine and the direct and selective activated blood clotting Xth factor obstruction medicine, general system(R in formula is the hydrogen atom or the low-grade alkyl group, as for Z as for the medicine which becomes it is the hydrogen atom or hydroxyl group) with the 5- amijino -2- hydroxy benzene sulfonamide derivative which is displayed or combining with the salt which that pharmacology is allowed, is useful in prevention or remedy of the thrombus embolism.本発明は、血栓塞栓症の予防または治療効果に優れた併用医薬を提供するものであり、抗血小板薬と、直接的かつ選択的な活性化血液凝固第X因子阻害薬である、一般式(式中のRは水素原子または低級アルキル基であり、Zは水素原子または水酸基である)で表される5-アミジノ-2-ヒドロキシベンゼンスルホンアミド誘導体またはその薬理学的に許容される塩とを組み合わせてなる医薬は、血栓塞栓症の予防または治療に有用である。
