CHARLES KERBAGE,DENNIS J. NILAN,GERALD D. CAGLE,PAUL D. HARTUNG,VINCENT VALVO
申请号：
BR112013003754
公开号：
BR112013003754A2
申请日:
2011.08.12
申请国别(地区):
BR
年份:
2016
代理人:
摘要：
This invention provides a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises for example illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye previously and specifically binding to the amyloid protein indicative of the amyloidogenic disorder； and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.
