Dennis J. Nilan;Charles Kerbage;Paul D. Hartung;Gerald D. Cagle;Vincent Valvo
发明人:
Paul D. Hartung,Vincent Valvo,Charles Kerbage,Gerald D. Cagle,Dennis J. Nilan
申请号：
US13814677
公开号：
US09220403B2
申请日:
2011.08.12
申请国别(地区):
US
年份:
2015
代理人:
摘要：
In accordance with an embodiment of the invention, there is provided a device and method for detecting an amyloid protein in an eye of a mammal. A method comprises illuminating the eye with a light source having at least one of a wavelength property, a polarization property or a combination thereof, each appropriate to produce fluorescence in at least an amyloid-binding compound when the amyloid-binding compound is bound to the amyloid protein, the amyloid-binding compound having been introduced to the eye and specifically binding to the amyloid protein indicative of the amyloidogenic disorder； and determining a time decay rate of fluorescence for at least the fluorescence produced by the amyloid-binding compound bound to the amyloid protein, the determining permitting distinguishing of the presence of the amyloid-binding compound bound to the amyloid protein in the eye based on at least the time decay rate.
