The present invention relates to the compositions for preventing or treating hyperlipidemia, fatty liver or artery sclerosis, and it includes secrete acid to adjust peptide derivant as active constituent. Compared with naturally secreting acid and adjusting peptide, it secretes acid and adjusts the ability that peptide derivant has high activation GLP-1 receptors and glucagon receptor, and there is the effect for the ratio between reducing through the raised blood total cholesterol of high fat diet, low density cholesterol and serum triglyceride level, and improving high density cholesterol level and high density cholesterol/low density cholesterol. Therefore, secreting acid adjusting peptide derivant can effective what treatment hyperlipidemia and related disease.本發明涉及預防或治療高脂血症、脂肪肝病或動脉硬化的組合物，其包含泌酸調節肽衍生物作爲活性成分。與天然泌酸調節肽相比，泌酸調節肽衍生物具有高的激活GLP-1受體和胰高血糖素受體的能力，並具有降低通過高脂肪膳食而升高的血液總膽固醇、低密度膽固醇和三酰甘油水平，和提高高密度膽固醇水平以及高密度膽固醇／低密度膽固醇之比的作用。因此，泌酸調節肽衍生物可有效用於治療高脂血症和相關疾病。
