KIM, Dae Hoon,KIM, Chun Hwa,LEE, Sun Hee,YANG, Goeun,KANG, Seung Jun,CHOI, Hyo Sun
申请号：
SG11202004891P
公开号：
SG11202004891PA
申请日:
2018.12.03
申请国别(地区):
SG
年份:
2020
代理人:
摘要：
The present invention provides a use of a 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative for protecting pancreatic beta cells. A 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative according to the present invention resolves a side effect in which conventionally developed agents for treating diabetes induce apoptosis of pancreatic beta cells through excitotoxic reactions, thereby causing a secondary failure in which an insulin secretory function is not controlled. A 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative according to the present invention promotes insulin secretion only when glucose concentration is increased, thereby protecting the pancreatic beta cells from apoptosis and restoring the insulin secretory function of the pancreatic beta cells. Therefore, according to the present invention, the 3-(4-(benzyloxy)phenyl)hex-4-inoic acid derivative: exhibits an excellent pancreatic beta cell protection effect, when administered as a primary selective agent for diabetes and also when administered to a patient having pancreatic beta cells damaged by the use of other drugs, which are primary selection agents for diabetes and cause a secondary failure； and restores the insulin secretory function of pancreatic beta cells, thereby being useful for treating type II diabetes in a patient of which the blood glucose is not regulated in a normal manner by using an agent for promoting insulin secretion.
