CORTEZ, Guillermo S.,DAHNKE, Karl Robert,GROGAN, Michael John,RODRIGUEZ HERGUETA, Antonio,JAMISON, James Andrew,WATSON, Brian Morgan,WOODS, Timothy Andrew,BONDAY, Zahid Quyoom
申请号：
PE0023302017
公开号：
PE02312018A1
申请日:
2016.04.27
申请国别(地区):
PE
年份:
2018
代理人:
摘要：
Refers to a compound of formula (i), where: A1A is r1b is ciclopropoxi Chlorine R2 and R3 is Hydrogen Amine.These are nucleoside 5 - substituted Compounds, Pharmaceutical compositions comprising the compounds.It also relates to methods of using the compounds to treat cancer, sarcomas, including glioblastoma, melanoma, gastric cancer, pancreatic cancer, cholangiocarcinoma,Bladder cancer, Breast Cancer, non small cell lung cancer, Leukemia, including acute myeloid leukemia and lymphomas.Referido a un compuesto de formula (I), donde: R1a es ciclopropoxi R1b es cloro R2 es hidrogeno y R3 es amino. Estos compuestos son nucleosidos 5-sustituidos, composiciones farmaceuticas que comprenden los compuestos. Tambien se refiere a metodos de utilizacion de los compuestos para tratar el cancer, en particular glioblastomas, melanoma, sarcomas, cancer gastrico, cancer de pancreas, colangiocarcinoma, cancer de vejiga, cancer de mama, cancer de pulmon de celulas no pequenas, leucemias que incluyen leucemia mieloide aguda y linfomas.
