Refers to a compound [I-A], [I-B], or [I-C] formulated with R1,R1a is C1-4 tar, r1b is C1-4 tar, or trifluoroalkyl, r1c is C1-4 tar, C1-4 is fluorescent tar, C1-4 is alcox C1-4, or alcox C1-4 is c1-4-tar, or formula (2),N is 1, 2, 3, 4 or 5, and r1d is fluorine, C1-4 tar, C1-4 fluoroquilo, alcox C1-4 or alcox c1-4-c1-4-tar. R2 is a hydrogen or C1-4 tar. R3 is hydrogen, halogen, C1-4 tar, or alcox C1-4. R4 is the formula (3),R4A is a hydrogen, C1-4 or alcox C1-4, or a formula (4),R5 is C1-6, R6 is C1-6, cycloquilo c3-5, or alcox c1-4-c1-4-tar. X is CH2 or if R2 (I-A) in the formula is C1-4 tar, then R3 is hydrogen. It is a hydroxytricyanide compound with inhibitory activity on prostaglandin E2 sintasa-1 (mPGES-1),It can help prevent or treat pain, rheumatism, osteoarthritis, glaucoma, systemic sclerosis and / or cancer, including rectal cancer.Referido a un compuesto de la formula [I-a], [I-b], o [I-c], caracterizado porque R1 es la formula (1), en donde R1a es alquilo C1-4； R1b es alquilo C1-4, o trifluorometilo, y R1c es alquilo C1-4, fluoroalquilo C1-4, alcoxi C1-4, o alcoxi C1-4-alquilo C1-4； o la formula (2), en donde n es 1, 2, 3, 4 o 5, y R1d es fluoro, alquilo C1-4, fluoroalquilo C1-4, alcoxi C1-4, o alcoxi C1-4-alquilo C1-4. R2 es hidrogeno o alquilo C1-4. R3 es hidrogeno, halogeno, alquilo C1-4, o alcoxi C1-4. R4 es la formula (3), en donde R4a es hidrogeno, alquilo C1-4 o alcoxi C1-4, o la formula (4), en donde R5 es alquilo C1-6, R6 es alquilo C1-6, cicloalquilo C3-5, o alcoxi C1-4-alquilo C1-4. X es CH2 u O, siempre que, cuando R2 en la formula (I-a) es alquilo C1-4, entonces R3 sea hidrogeno. Este, es un compuesto de hidroxitriazina y tiene una actividad inhibidora sobre la prostaglandina microsomal E2 sintasa-1 (mPGES-1), y es de utilidad para la prevencion o el tratamiento de dolor, reumatismo, osteoartritis, glaucoma, esclerodermia sistemica y/o cancer incluyendo cancer colorrectal, entre otros.
