Refers to a compound of formula I, where ra represents - C (= o) - O - C (R4) (R5) - or - C (= o) - C (R3) (NH2) - R6, R1 is methoxy and 2,2,2-trifluoroethoxy R2 IS), azetidin - 1 - carbonyl or fluoroazetidin - 3 - 1 - carbonyl R3 is Hydrogen or Methyl R4 and R5 is Hydrogen or alkyl of C1 - C3 and R6 is Hydrogen or alq Uilo C1 - C6.It is a Preferred Compound 3 - methyl - l-valinate ({[4 - [(3 - fluoroazetidin - 1 - il) carbonyl] - 2 - (2,2,2-trifluoroethoxy) phenyl} {[1 - (4 - [(2R) - 2 - (4-fluorophenyl) phenyl] amino} propanoil [1,2,4] triazolo [1,5-a] pyridin-2-yl] carbamoyl) oxy] methyl.These compounds inhibit the kinase MPS - 1, being useful in the treatment on the growth, proliferation, Survival and \/ or uncontrolled Cell such as hematological Tumors, Leukemia, Solid Tumors, among others.Se refiere a un compuesto de formula I, donde: RA representa -C(=O)-O-C(R4)(R5)-O-C(=O)-C(R3)(NH2)-R6 R1 es metoxi y 2,2,2-trifluoroetoxi R2 es metilsulfonil, azetidin-1-carbonil o 3-fluoroazetidin-1-carbonil R3 es hidrogeno o metilo R4 y R5 son hidrogeno o alquilo C1-C3 y R6 es hidrogeno o alquilo C1-C6. Es un compuesto preferido el 3-metil-L-valinato de [({4-[(3-fluoroazetidin-1-il)carbonil]-2-(2,2,2-trifluoroetoxi)fenil}[7-(4-{[(2R)-2-(4-fluorofenil)propanoil]amino}fenil)[1,2,4]triazolo[1,5-a]piridin-2-il]carbamoil)oxi]metilo. Dichos compuestos inhiben la Mps-1 quinasa, siendo utiles en el tratamiento contra el crecimiento, proliferacion y/o supervivencia celular descontrolada tales como tumores hematologicos, tumores solidos, leucemia, entre otros.
