Aniko Goblyos;Johannes Brussee;Adriaan P. Ijzerman;Zhan-Guo Gao;Kenneth Jacobson
发明人:
Aniko Goblyos,Johannes Brussee,Adriaan P. Ijzerman,Zhan-Guo Gao,Kenneth Jacobson
申请号：
US12219772
公开号：
US08420664B2
申请日:
2008.07.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to allosteric modulation of A3 adenosine receptor (A3AR) and provides for the use of an A3 adenosine receptor modulator (A3RM), for the preparation of pharmaceutical compositions for modulating the A3AR in a subject, as well as pharmaceutical compositions comprising the same and therapeutic methods comprising administering to a subject an amount of an A3RM, the amount being effective to modulate A3AR activity. The A3RM according to the invention are 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives. The invention also provides some of such novel 1H-Imidazo-[4,5-c]quinolin-4-amine derivatives.
