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FLUORINATED LIGANDS FOR TARGETING PERIPHERAL BENZODIAZEPINE RECEPTORS
专利权人:
OSTREHJLIEN N'JUKLIAR SAJENS EHND TEKNOLODZHI ORGANIZEJSHN;OSTREHJLIEN NJUKLIAR SAJENS EHND TEKNOLODZHI ORGANIZEJSHN
发明人:
KATsIFIS Ehndrju (AU),КАЦИФИС Эндрю (AU),FUKS Kristofer Dzhon Redzhinal'd (AU),ФУКС Кристофер Джон Реджинальд (AU),FAM Tien Kuok (AU),ФАМ Тиен Куок (AU),GREGURIK Ivan Damir (AU),ГРЕГУРИК Иван Дамир (A,KATSIFIS EHNDRJU,КАЦИФИС Эндрю,FUKS KRISTOFER DZHON REDZHINALD,ФУКС Кристофер Джон Реджинальд,FAM TIEN KUOK,ФАМ Тиен Куок,GREGURIK IVAN DAMIR,ГРЕГУРИК Иван Дамир,MATTNER MARIJA FILOMENA PEREJRA SOARES
申请号:
RU2009110480/04
公开号:
RU0002468014C2
申请日:
2007.08.24
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: present invention relates to fluorinated compounds of formula , where: D, G and L are independently selected from a group consisting of: CH, C and N, and J and M are independently selected from a group consisting of C and N, under the condition that one of J and M denotes C and the other denotes N, wherein at least two of D, G, M, J and L denote N; X denotes CH2; Y is absent; Z denotes NR1R2; R1 and R2 are independently selected from a group consisting of: hydrogen, C1-C10 alkyl, aryl and heteroaryl, which is associated with aromatic radicals having 6 ring atoms, where 1-2 of these ring atoms are N; each of which can be substituted with one or more halogen atoms; or R1 and R2, together with nitrogen to which they are bonded, form a heterocyclic ring having 5 ring members; R3 is selected from a group consisting of: halogen, C1-C10 alkyl; E denotes aryl which can be substituted with one or more fluoro-substitutes or one or more of the following substitutes: C1-C6 alkyl, QC1-C10 alkyl, QC2-C10 alkenyl, each of which can be substituted with one or more fluoro-substitutes, and where Q denotes O; m denotes a number from 1 to 2; under the condition that: R3 is a fluoro-substitute, or group E includes a fluoro-substitute, or group Z includes a fluoro-substitute, with the condition that E does not denote 4-fluorophenyl or a compound of formula , where D, G and L are independently selected from a group consisting of: CH, C and N, and J and M are independently selected from a group consisting of C and N, under the condition that one of J and M denotes C and the other denotes N, wherein at least two of D, G, M, J and L denote N; X denotes CH2; Y is absent; Z denotes NR1R2; R1 and R2 are independently selected from a group consisting of: hydrogen, C1-C10 alkyl, aryl and heteroaryl, which is associated with aromatic radicals having 6 ring atoms, where 1-2 of these ring atoms are N; each of which can be substituted with one or more of the following subs
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