CHEN, Li,DILLON, Michael Patrick,FENG, Lichun,HAWLEY, Ronald Charles,YANG, Minmin
申请号：
ES08862496
公开号：
ES2570628T3
申请日:
2008.12.08
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Compound of formula I: ** Formula ** or pharmaceutically acceptable salts thereof, wherein: R1 is optionally substituted imidazolyl, R2 is optionally substituted phenyl, optionally substituted pyridinyl, optionally substituted pyrimidinyl, optionally substituted pyridazinyl or optionally substituted thiophenyl, R3 is hydrogen, C1-6 alkyl or C1-6 heteroalkyl or cyano, R4 is hydrogen, C1-6 alkyl or C1-6 heteroalkyl, or R3 and R4 together with the atom to which they are attached can form a C3- carbocyclic ring 6； R5 is C1-6 alkyl； C 1-6 heteroalkyl, C 1-6 haloalkyl, N-C 1-6 alkyl-amino, N, N-di- (C 1-6 alkyl) -amino, C 3-7 cycloalkyl, aryl, heteroaryl, heterocyclyl, C 3-7 cycloalkyl C1-6 alkyl, heteroaryl-C1-6 alkyl, heterocyclyl-C1-6 alkyl, aryl-C1-6 alkyl, aryloxy-C1-6 alkyl, - (CRaRb) mC (O) -R8 in which m is 0 or 1, Ra and Rb, each independently, is hydrogen, or C 1-6 alkyl, and R 8 is hydrogen, C 1-6 alkyl, C 1-6 heteroalkyl, C 3-7 cycloalkyl, aryl, heteroaryl, heterocyclyl, C 3-7 cycloalkyl. C 1-6 alkyl, aryl C 1-6 alkyl, heteroaryl C 1-6 alkyl, heterocyclyl C 1-6 alkyl, C 3-7 cycloalkyloxy, aryloxy, heteroaryloxy, heterocyclyloxy C 3-7 cycloalkyloxy, C 1-6 alkyl, aryloxyC 1-6 alkyl -6, heteroaryloxy-C1-6 alkyl, heterocyclyloxy C1-6 alkyl, or -NR9R10, wherein R9 is hydrogen or C1-6 alkyl, and R10 is hydrogen, C1-6 alkyl, C1-6 heteroalkyl, C3- cycloalkyl 7, aryl, heteroaryl, heterocyclyl, C3-7 cycloalkyl-C1-6 alkyl, aryl-C1-6 alkyl, heteroaryl-alkyl or hetero cyclyl-C1-6 alkyl, or R4 and R5 together with the atom to which nests can form a C3-6 carbocyclic ring that is optionally substituted with hydroxy, or R4 and R5 together with the atom to which they are attached can form a C4-6 heterocyclic ring containing one or two heteroatoms selected, each independently, from O, N and S, or R3, R4 and R5 together with the atom to which they are attached can form a six-element heteroaryl containing one or two nitrogen atoms and which is optionally substituted with halo, ami
