The present disclosure relates to certain chiral diaryl macrocyclic derivatives, pharmaceutical compositions containing them, and methods of using them to treat cancer, pain, neurological diseases, autoimmune diseases, and inflammation.本發明係關於某些掌性二芳基巨環衍生物、含有其之醫藥組合物,及使用其治療癌症、疼痛、神經疾病、自體免疫疾病及發炎之方法。