An ultrasonic irradiation apparatus irradiates an ultrasonic wave to a target portion where micro bubbles or micro grains which reflect or scatter an ultrasonic wave exist. The apparatus includes an input unit, a drive signal setting unit, and an ultrasonic emission unit. The input unit receives information about a resonance frequency of fB of the micro bubbles or the micro grains where fB is a positive real number. The drive signal setting unit generates a drive signal including a signal component whose frequency is f=n×fB where n is an integer not smaller than 2. The ultrasonic emission unit emits the ultrasonic wave including a sonic wave component whose frequency is the f based on the drive signal.
