An ultrasonic irradiation apparatus includes an ultrasonic emission part, an ultrasonic reception part, a low frequency signal detector, and a condition change unit. The ultrasonic emission part emits a first ultrasonic wave including a first frequency component having a frequency of f toward a target portion based on an ultrasonic setting value where f is a positive real number. The ultrasonic reception part receives a second ultrasonic wave which travels in a direction from the target portion. The low frequency signal detector detects a low frequency signal included in the second ultrasonic wave, the lower frequency signal having a frequency not greater than f/r where r is a real number and is greater than 2. The condition change unit changes the ultrasonic setting value based on the low frequency signal.