MLYNARSKI, Scott Nathan,GREBE, Tyler,KAWATKAR, Sameer,FINLAY, Maurice Raymond Verschoyle,SIMPSON, Iain,WANG, Jianyan,COOK, Steve,WU, Dedong
申请号：
SG11202007739X
公开号：
SG11202007739XA
申请日:
2019.02.15
申请国别(地区):
SG
年份:
2020
代理人:
摘要：
Disclosed are compounds of formula (Ia) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of formula (Ia) and methods of using the same for treating cancer or a respiratory inflammatory disease and inhibiting arginase, wherein R1 is -NHR1a； R1a is -H or -C(O)CH(R1b)NHR1c； and R1b is selected from -H, -(C1-C4 ) alkyl and CH2OR1d and R1cis -H； or R1b and R1c, together with the atom to which they are attached, form a 5-membered heterocyclic ring； and R1d is H or -CH3.
