PROBLEM TO BE SOLVED: To provide a solid oral medicinal composition from which the leachability of ibuprofen is maintained even after low-temperature preservation, and to provide a method for producing the medicinal composition.SOLUTION: The method for producing the solid oral medicinal composition includes mixing (A) ibuprofen, (B) an aminoalkyl methacrylate copolymer E and (C) a vehicle, heating the obtained mixture under conditions of the heating temperature and heating time satisfying the relationship between the heating temperature (X°C) and the heating time (Y h) represented by Y≥0.0052X2-1.114X+60.57 (wherein, X is 50-100 and Y is a value obtained by rounding the number after the decimal point), and pulverizing the obtained heated mixture.COPYRIGHT: (C)2013,JPO&INPIT【課題】低温保存後でもイブプロフェンの溶出性が維持された、固体内服医薬組成物及びその製造方法を提供する。【解決手段】(A)イブプロフェンと、(B)アミノアルキルメタクリレートコポリマーEと、(C)賦型剤とを混合し、得られた混合物を、加熱温度(X℃)と加熱時間(Y時間)との関係が、Y≧0.0052X2-1.114X+60.57(但し、Xは50~100であり、Yは小数点第1位を四捨五入した値)を満たす、加熱温度及び加熱時間で加熱し、得られた加熱混合物を粉砕する、固体内服医薬組成物の製造方法。【選択図】図1
