A system for local thermal treatment includes a solid-state heat pump, a controller, a power supply, a heat sink, a thermal conductor, and a thermal pack. The solid-state heat pump may increase or decrease the temperature of the thermal pack to a desired temperature for providing heat or cold treatment. The controller provides control of the solid-state heat pump and its associated components. The heat sink may include an air heat exchanger with fins and a fan, and a liquid heat exchanger with a coolant loop and pump. The coolant loop may allow the heat sink to be separated from the thermal pack for convenient use in constrained spaces. The thermal conductor and thermal pack may be flexible and may be configured specifically to conform to individual body parts. The thermal pack provides local thermal treatment to a subject's body for an extended duration.