DAL FARRA, Claude,DOMLOGE, Nouha,BOTTO, Jean-Marie
申请号：
ES12725474
公开号：
ES2571383T3
申请日:
2012.04.27
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
Peptide compound of the following general formula (I): R1- (AA) n-X1-X2-X3-Lys-Lys-Gln-Lys-Trp-X4- (AA) p-R2 in which, X1 represents an asparagine , binds glycine, a threonine, an alanine or no amino acid, X2 represents an isoleucine, a leucine, a methionine, a proline or no amino acid, X3 represents a threonine, an asparagine, a serine or no amino acid, X4 represents a serine, a cysteine, a threonine, an asparagine, a glutamine or no amino acid, AA represents any one amino acid, and p and n are integers between 0 and 2, R1 represents the primary amine function of the N-terminal amino acid, -NH2, in which one of the two hydrogen atoms may be substituted or unsubstituted, either by a saturated or unsaturated C1 to C30 alkyl chain of the acetyl type or by an aromatic group of the benzoyl, tosyl or benzyloxycarbonyl type, R2 represents the hydroxyl group of the carboxyl function of the C-terminal amino acid, -OH, in the that the hydrogen atom may be substituted or unsubstituted, either by a C1 to C30 alkyl chain or by an NH2, NHY or NYY group in which Y represents a C1 to C4 alkyl chain, said sequence of general formula being constituted (I) for 5 to 13 amino acid residues, characterized in that it corresponds to one of the following formulas: (SEQ ID No. 1) Asn-Thr-Lys-Lys-Gln-Lys-Trp-Thr-Asn-NH2； (SEQ ID No. 2) Lys-Lys-Gln-Lys-Trp-NH2； (SEQ ID No. 3) Gly-Gly-Leu-Lys-Lys-Gln-Lys-Trp-Asn-Leu-Tyr； (SEQ ID No. 4) Ala-Met-Lys-Lys-Gln-Lys-Trp-NH2； (SEQ ID No. 5) Ala-Leu-Ser-Lys-Lys-Gln-Lys-Trp-Gln； (SEQ ID No. 6) Cys-Lys-Lys-Gln-Lys-Trp-Ser-NH2.Compuesto peptídico de la fórmula general (I) siguiente: R1-(AA)n-X1-X2-X3-Lys-Lys-Gln-Lys-Trp-X4-(AA)p-R2 en la cual, X1 representa una asparagina, une glicina, una treonina, una alanina o ningún aminoácido, X2 representa una isoleucina, una leucina, una metionina, una prolina o ningún aminoácido, X3 representa una treonina, una asparagina, una serina o ningún aminoácido, X4 representa una serina, una cisteína, una treonina, una as
