JENNIFER R. ALLEN,FANG HONG,PATRICIA TSAO - LOPEZ,PHILIP R. OLIVIERI,ZIHAO HUA,OLEG EPSTEIN,RYAN WHITE,JASON BROOKS HUMAN,KARINA ROMERO,LAURIE SCHENKEL,JOHN STELLWAGEN,NURIA A. TAMAYO,XIAO MEI ZHENG
申请号：
ARP140100307
公开号：
AR095093A1
申请日:
2014.01.29
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
1. Requirement 1: a compound (1) with formula characteristics,O O O 1 stereoisomer, tauqianros, hydrate, solution or drug acceptable salt, wherein a83099 is cr83090 or N； a8310 is cr8310 or N； a83212 is cr831222 or N, but not more than one of a83099；A8310 and a831222 n； each R1,independently, it is H, F, Cl, C₁₋₆ alkyl,C₂₋₄ alkenyl,1. C 83228331 asphalt；CN, -CH₂O-C₁₋₆-alkyl,-O-alkyl C₁₋₆,-S (O) ₒ-C₁₋₆-alkyl,-NH-C₁₋₆-alkyl,-C (O) C₁₋₆ alkyl or C₃₋₆ cycloalkyl,where each of the C alqu alkyl portions,C₂₋₄ alkenyl,1. C 83228331 asphalt；C₃₋₆ cycloalkyl and C₁₋₆ alkyl of -CH₂O-C₁₋₆ alkyl,-O-alkyl C₁₋₆,-S (O) ₒ-C₁₋₆-alkyl,-NH-C₁₋₆-alkyl and -C (O) C₁₋₆-alkyl is optionally substituted with 1-4 substituents of F, oxo or OH； alternatively, each R¹ taken together with the carbon atom to which it is attached forms a spirocarbocyclic ring C₃₋₆ which optionally includes a hetero atom selected from O and N and which is optionally independently substituted with 1-4 substituents of F, OH, C₁₋₃ alkyl,C₁₋₃ alkoxy,a. C8322； o-lessor c83231；R2 is lease No. c83217c83318324,CH₂O-C₁₋₄ alkyl,CH₂OH, CH₂CN, C₃₋₆ cycloalkyl or CN, where each of C₁₋₄ alkyl,CH₂O-C₁₋₄-alkyl and C₃₋₆-cycloalkyl is optionally substituted with 1-4 F atoms； each R³,Independently, this is halo, lease No. c1832131, lease No. 832431,O-alkyl C alqu,CH₂O-C₁₋₄ alkyl,CH₂OH, haloalkyl C₁₋₄,cyclopropyl or CN, where each of C₁₋₄-O-alkyl,CH₂O-C₁₋₄-alkyl and cyclopropyl is optionally substituted with 1-4 F atoms； each of R⁵,R8310 and r831222,independently, it is H, halo, haloalkyl, haloalkoxy, C₁₋₄-alkyl,CN, OH, O-C₁₋₄-alkyl,S (O) -alquilo CNH-C₁₋₄-alkyl or C (O) C₁₋₄-alkyl；R⁷ is -NH-R⁹,-NHC (3DO) -R-C (3DO) NH-R-O-R⁹ or -S-R⁹；R⁹ is acetyl, C₁₋₆ alkyl,C₂₋₄ alkenyl,C₂₋₄-alkynyl or a 5-, 6- or 7-membered monocyclic or fully or partially unsaturated ring consisting of carbon atoms, where said ring optionally includes 1-4 heteroatoms if monocyclic or 1 - 5 heteroatoms if bicyclic, where said heteroatoms are selected from O, N or S,
