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GELATING COLLAGEN AND MEANS FOR PREPARING IT
专利权人:
АМЕДРИКС ГМБХ (DE)
发明人:
ГРЕВЕ Томас (DE)
申请号:
RU2013141169/15
公开号:
RU2013141169A
申请日:
2012.01.26
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
1. A method of producing a directly gelling collagen gel from a liquid concentrated collagen solution and a liquid buffer solution, comprising the following steps: - obtaining a collagen solution and a buffer solution separately from each other, - temperature control of a collagen solution and a buffer solution at a temperature of from 20ºC to 37ºC, - mixing a thermostatically controlled collagen solution and a thermostatic buffer solution, whereby a gelatinous collagen composition is formed which can directly o gel. 2. The method according to claim 1, wherein the collagen solution has a concentration above 8 mg / ml. The method according to claim 2, wherein the pH of the collagen solution (calculated at 21ºC) is 6 or less. The method according to one of the preceding paragraphs, wherein the buffer solution is a neutralizing buffer solution. The method according to claim 1, wherein the collagen solution and the buffer solution are mixed in a ratio of from 1: 1 to 9: 1.6. A method according to claim 1, wherein the resulting collagen composition has a collagen concentration of 6 mg / ml or more. The method of claim 1, wherein the mixing is completed in a period of maximum 5 seconds. The method according to claim 1, wherein the gelation of the obtained collagen composition begins within 10 seconds. The method according to claim 1, wherein the collagen composition hardens to a solid gel within 2-4 minutes. The method according to claim 1, wherein the collagen solution and the buffer solution are obtained separately from each other in a multi-chamber syringe. The method of claim 10, wherein thermostating the collagen solution and the buffer solution is carried out inside the syringe. The method of claim 10 or 11, wherein combining and mixing the collagen solution and the buffer solution1. Способ получения непосредственно желатинирующего коллагенового геля из жидкого концентрированного раствора коллагена и жидкого буферного раствора, содержащий следующие стадии:- получени
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