Anvendelse av poly(ADP-ribose)polymerase (PARP) inhibitorer for fremstilling av et medikament for anvendelse i behandling av cancer og fremgangsmåte for å fastslå aktiviteten av den HR-avhengig DNA DSB reparasjonsveien i en cancertilstand og fremgangsmåte for å fastslå responsen av en cancertilstand i et individ.

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专利权人:

Kudos Pharmaceuticals Ltd

发明人:

Ashworth, Alan,Jackson, Stephen,Martin, Niall,Smith, Graeme

申请号：

NO20063078

公开号：

NO335959B1

申请日:

2006.07.03

申请国别(地区):

NO

年份:

2015

代理人:

摘要：

The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.

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http://www.ckcest.cn/home/