Inhibitory naprawy uszkodzeń DNA w leczeniu raka

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专利权人:

The Institute of Cancer Research;Kudos Pharmaceuticals Limited

发明人:

ASHWORTH, ALAN,JACKSON, STEPHEN,MARTIN, NIALL,SMITH, GRAEME

申请号：

PL10178515

公开号：

PL2305221T3

申请日:

2004.11.30

申请国别(地区):

PL

年份:

2015

代理人:

摘要：

The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.

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来源网址：

http://www.ckcest.cn/home/