Jinzi Jason Wu,Brent Richard Stranix,Michael Ge,Guy Milot,Marco Petrella,Chandra J. Panchal
申请号：
US13216743
公开号：
US20120053139A1
申请日:
2011.08.24
申请国别(地区):
US
年份:
2012
代理人:
摘要：
The present invention provides methods for improving the pharmacokinetics of protease inhibitors and protease inhibitor precursors and pharmaceutical composition comprising protease inhibitors or protease inhibitor precursors of formula I and a cytochrome P450 monooxigenase inhibitorwhen the compound of formula I comprises an amino group, pharmaceutically acceptable ammonium salts thereof, wherein R1 may be, for example, (HO)2P(O)—, (NaO)2P(O)—, alkyl-CO— or cycloalkyl-CO—, wherein X may be, for example, F, Cl, and Br, and wherein R2 and R3 are as defined herein.
