Ding, Yun,Thalji, Reema, K.,Marino, Joseph, Paul, Jr.
申请号：
UA201005720
公开号：
UA107444C2
申请日:
2008.10.10
申请国别(地区):
UA
年份:
2015
代理人:
摘要：
The invention is directed to novel sEH inhibitors and their use in the treatment of diseases mediated by the sEH enzyme. Specifically, the invention is directed to compounds according to Formula I: wherein R1, R2, R4, R5, R6, Α, Β, Υ, Ζ, n, and m are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are sEH inhibitors and can be used in the treatment of diseases mediated by the sEH enzyme, such as hypertension. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting sEH and treatment of conditions associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.Конкретно, изобретение касается соединений, отвечающих формуле I: в которой R1, R2, R4, R5, R6, А, В, Υ, Ζ, n и m имеют указанные в описании значения, и их фармацевтически приемлемых солей.Конкретно, винахід стосується сполук, що відповідають формулі І: у якій R1, R2, R4, R5, R6, А, В, Υ, Ζ, n і m мають вказані в описі значення, і їхніх фармацевтично прийнятних солей.
