Thalji, Reema K.,Marino Jr., Joseph Paul,Ding, Yun
申请号：
AU2008310732
公开号：
AU2008310732B2
申请日:
2008.10.10
申请国别(地区):
AU
年份:
2012
代理人:
摘要：
The invention is directed to novel sEH inhibitors and their use in the treatmentof diseases mediated by the sEH enzyme. Specifically, the invention is directedto compounds according to Formula I: wherein R1, R2, R4, R5, R6, A, B, Y, Z, n, andm are defined below, and to pharmaceutically-acceptable salts thereof. Thecompounds of the invention are sEH inhibitors and can be used in the treatmentof diseases mediated by the sEH enzyme, such as hypertension. Accordingly, theinvention is further directed to pharmaceutical compositions comprising acompound of the invention. The invention is still further directed to methodsof inhibiting sEH and treatment of conditions associated therewith using a compoundof the invention or a pharmaceutical composition comprising a compound of theinvention.
