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SOLID ORAL DOSAGE FORMS OF ESLICARBAZEPINE
专利权人:
JUBILANT GENERICS LIMITED
发明人:
Ravikumar NITHIYANANDAM,Ganesh Vinayak GAT,Dinesh KUMAR,Kamal S. MEHTA,Premchand Dalichandji NAKHAT,Vivek JAIN,Priyank SHARMA,Baibhav JOSHI
申请号:
US15742004
公开号:
US20180280307A1
申请日:
2016.12.16
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present invention relates to high drug load pharmaceutical compositions comprising Eslicarbazepine or its pharmaceutically acceptable salts, esters, solvates, polymorphs, enantiomers or mixtures thereof. The present invention also relates to a process for preparing high drug load solid oral pharmaceutical composition comprising Eslicarbazepine acetate and at least one pharmaceutically acceptable excipient. The prior art highlights various technical challenges for formulation development of Eslicarbazepine acetate at lab as well as at industrial scale and offer restrictive and complex approach for resolution of technical challenges. Compositions of Eslicarbazepine acetate prepared as per present invention, wherein disintegrant and/or binder is present in either intra-granular part or in extra-granular part of the composition exhibited desirable technical attributes like comparable dissolution and bioequivalence against reference listed drug.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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