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专利权人:
BASILEA PHARMACEUTICA AG
发明人:
JENS POHLMANN,FELIX BACHMANN
申请号:
MX2012000611
公开号:
MX2012000611A
申请日:
2010.07.26
申请国别(地区):
MX
年份:
2012
代理人:
摘要:
A compound of formula (II) wherein (a) represents a divalent benzene residue which is unsubstituted or substituted by one or two additional substituents independently selected from lower alkyl, halo-lower alkyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl, acyloxy-lower alkyl, phenyl, hydroxy, lower alkoxy, hydroxy-lower alkoxy, lower alkoxy-lower alkoxy, phenyl-lower alkoxy, lower alkylcarbonyloxy, amino, mono(lower alkyl)amino, di(lower alkyl)amino, mono(lower alkenyl)amino, di(lower alkenyl)amino, lower alkoxycarbonylamino, lower alkylcarbonylamino, substituted amino wherein the two substituents on nitrogen form together with the nitrogen heterocyclyl, lower alkylcarbonyl, carboxy, lower 15 alkoxycarbonyl, cyano, halogen, and nitro or wherein two adjacent substituents can be methylenedioxy or a divalent pyridine residue (Z = N) which is unsubstituted or substituted additionally by lower alkyl, lower alkoxy, lower alkoxy-lower alkoxy,amino, optionally substituted by one or two substituents selected from lower alkyl, lower alkenyl and alkylcarbonyl, halo-20 lower alkyl, lower alkoxy-lower alkyl, or halogen R1 represents hydrogen, lower alkylcarbonyl, hydroxy-lower alkylor cyano-loweralkyl and R2 represents a group selected from: (b), (c) and (d) or pharmaceutically acceptable salts thereof.La presente invención se refiere a un compuesto de la fórmula (II) en donde (a) representa un residuo de benceno divalente que está substituido o no substituido por uno o dos substituyentes adicionales seleccionados independientemente de alquilo inferior, halo-alquilo inferior, hidroxi-alquilo inferior, alcoxi inferior-alquilo inferior, aciloxi-alquilo inferior, fenilo, hidroxi, alcoxi inferior, hidroxi-alcoxi inferior, alcoxi inferior-alcoxi inferior, fenil-alcoxi inferior, alquilcarboniloxi inferior, amino, mono(alquilo inferior)amino, di(alquilo inferior) amino, mono(alquenilo inferior) amino, di (alquenilo inferior) amino, alcoxicarbonilamino inferior, alquilcarbonilamino i
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