Their preparation, their use as Pharmaceuticals and Pharmaceutical compositions containing them. In addition, intermediaries are disclosed for Manufacturing the compounds of formula (1), and combinations comprising the compounds of formula (1).Claim 1: compounds of the formula (1), wherein: R1 represents CHF2, CF3, CH2f, CH2f, ch3chf ch3cf2 -, Ethyl -, propyl -, or ISO alkyl and R2 is replaced by one or more substituents and the substituents from the group consisting of halogen, Nitro, acyl, Hydro Xilo, oxo (= o), alkoxyl, cicloalcoxilo, aciloxilo carboniloxilo -, alkoxy, amino alkyl amino.Dialkyl amino, Formilo, acyl amino carbonyl alkoxy - or - amino R2 represents heterociclil alkyl substituted by one or more substituents and the substituents from the group consisting of halogeno, cyano, Nitro, hydroxyl, alkoxyl, alkyl alkoxy - carboniloxilo, carboniloxilo, am No, - amino alkyl, dialkyl amino- alkoxy carbonyl amino R2 represents phenyl or substituted by one or more substituents, the Substituent was selected from the group consisting alcandiilo, alquendiilo Ciano, hydroxyl, alkoxyl, alkyl, Hydroxy, alkoxy alkyl Formilo, carbonyl, carbonyl, alkyl carboniloxilo, alcox I carboniloxilo alkyl, dialkyl amino amino amino amino alkyl, alkyl amino alkylDialkyl amino alkyl, alkoxy - carbonyl amino R2 represents heterociclilo or optionally substituted by one or more substituents and the substituents from the group consisting of halogen, hydroxyl, amino, Nitro, cyano, alkyl, Hydroxy alkyl, alkoxy alkyl, amino alkyl Amino alkyl, alkyl, dialkyl amino acyl, alkyl, alkoxyl, aciloxilo, carboniloxilo alkoxy -,Amino, amino alkyl, dialkyl amino Acyl -, amino -, alkoxy carbonyl amino heterocycle, and where the phenyl ring is bonded to a carbon Atom and their Salts.Su preparacion, a su uso como productos farmacéuticos, y a composiciones farmacéuticas que las contienen. Además, se dan a conocer intermediarios para la fabricacion de los compuestos de la formula (1), y combinaciones que co
