Soluble CTLA4 molecules, compositions comprising said molecules and uses thereof

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专利权人:

发明人:

申请号：

EP05022529.1

公开号：

EP1666498A3

申请日:

1995.04.13

申请国别(地区):

EP

年份:

2012

代理人:

摘要：

The invention relates to soluble CTLA4 molecules which bind a B7 antigen and comprise an amino acid sequence that corresponds to a mutant CTLA4 extracellular domain, wherein the amino acid sequence corresponding to the mutant CTLA4 extracellular domain comprises the sequences Met-Tyr-Pro-Pro-Pro-Tyr and Ala-Ser-Pro-Gly-Lys-Ala-Thr-Glu.The invention further relates to pharmaceutical compositions comprising such a molecule and the use of such a molecule in therapy. Also, the invention relates to methods for regulating binding and interactions wherein such a molecule is used.

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