INHIBITORY CHIMERIC ANTIGEN RECEPTORS

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专利权人:

发明人:

申请号：

EP15798238.0

公开号：

EP3218394A1

申请日:

2015.11.09

申请国别(地区):

EP

年份:

2017

代理人:

摘要：

The invention relates to an inhibitory chimeric antigen receptor (N-CAR) comprising an extracellular domain comprising an antigen binding domain, a transmembrane domain, and, an intracellular domain wherein the intracellular domain comprises an Immunoreceptor Tyrosine-based Switch Motif ITSM, wherein said ITSM is a sequence of amino acid TX1YX2X3X4, wherein X1 is an amino acid X2 is an amino acid X3 is an amino acid and X4 is V or

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