Aspects of the invention include methods for applying to a subject a transdermal delivery device configured to deliver a non-sedative amount of a dexmedetomidine composition. In practicing methods according to certain embodiments, a non-sedative amount of a dexmedetomidine composition is transdermally applied to a subject and is maintained in contact with the subject in a manner sufficient to deliver a non-sedative amount of dexmedetomidine to a subject. Also provided are transdermal delivery devices having a non-sedative amount of dexmedetomidine sufficient for practicing the subject methods, as well as kits containing the transdermal delivery devices.本發明態樣包括對個體施用經皮輸送裝置,其組態可以輸送非鎮靜量之右美托咪啶(dexmedetomidine)組成物。在操作根據某些具體實施例之方法中,對個體經皮施用非鎮靜量之右美托咪啶組成物,並維持其與該個體接觸,其方式足以輸送非鎮靜量右美托咪啶給該個體。亦提供一種足以操作該方法之具有非鎮靜量右美托咪啶之經皮輸送裝置,及含有該經皮輸送裝置之套組。