SHUDO, JUTARO,首藤十太郎,SONG, WAN-NING,宋 皖宁,宋 皖寧,GONSALVES, ROSE MARIE,刚萨尔维斯 萝丝,剛薩爾維斯 蘿絲,HWANG, STEPHEN SHIPPING,黄 希平,黃 希平,宋 皖宁,宋 皖寧,刚萨尔维斯 萝丝,剛薩爾維斯 蘿絲,黄 希平,黃 希平
申请号：
TW106137654
公开号：
TW201817419A
申请日:
2017.10.31
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
Aspects of the invention include methods of managing pain in a subject by applying a transdermal delivery device containing a dexmedetomidine composition formulated to deliver a pain relieving effective amount of dexmedetomidine to a subject. In practicing methods according to certain embodiments, a transdermal delivery device having a dexmedetomidine composition is applied to a subject and is maintained in contact with the subject in a manner sufficient to deliver an amount of dexmedetomidine effective to manage pain in the subject. In some embodiments, methods include hydrating the subject, such as by administering a hydration fluid composition to the subject. Methods according to certain embodiments may also include co-administering an opioid to the subject. Also provided is transdermal delivery device configured to deliver dexmedetomidine sufficient for practicing the subject methods, as well as kits containing the transdermal delivery device.本發明之態樣包括透過將含有右美托咪啶組成物的經皮遞送裝置施用至個體以在個體體內處理疼痛的方法，該右美托咪啶組成物被調配成遞送疼痛緩解有效量的右美托咪啶。在實施依據某些具體例的方法時，具有右美托咪啶組成物的經皮遞送裝置被施用至個體並且以足以遞送某量之有效在個體體內處理疼痛之右美托咪啶的方式與個體維持接觸。在一些具體例中，方法包括使個體水合，諸如透過向個體投予水合液體組成物。依據某些具體例的方法也包括向個體共同投予類鴉片。亦提供被結構設計成遞送足以實施本方法之右美托咪啶的經皮遞送裝置以及含有該經皮遞送裝置的套組。
