The United States of America; as represented by The Secretary; Department of Health and Human Services
发明人:
GROS, Alena,ROSENBERG, Steven A.
申请号：
ES13725231
公开号：
ES2771251T3
申请日:
2013.04.30
申请国别(地区):
ES
年份:
2020
代理人:
摘要：
Methods of obtaining a cell population enriched for tumor-reactive T cells, the method comprising: (a) obtaining a bulk population of peripheral blood mononuclear cells (PBMCs) from a sample of peripheral blood； (b) specifically selecting CD8<；sup>；+<；/sup>；T cells that also express PD-1 and/or TIM-3 from the bulk population； and (c) separating the cells selected in (b) from unselected cells to obtain a cell population enriched for tumor-reactive T cells are disclosed. Related methods of administering a cell population enriched for tumor-reactive T cells to a mammal, methods of obtaining a pharmaceutical composition comprising a cell population enriched for tumor-reactive T cells, and isolated or purified cell populations are also disclosed.
