United States of America; as represented by the Secretary; Department of Health and Human Services; C/O National Institute of Health; Office of Technology Transfer
发明人:
ROSENBERG, Steven A.,GROS, Alena
申请号：
AU2020220209
公开号：
AU2020220209A1
申请日:
2020.08.21
申请国别(地区):
AU
年份:
2020
代理人:
摘要：
#$%^&*AU2020220209A120200910.pdf#####30 ABSTRACT OF THE DISCLOSURE Methods of obtaining a cell population enriched for tumor-reactive T cells, the method comprising: (a) obtaining a bulk population of T cells from a tumor sample； (b) specifically selecting CD8' T cells that express any one or more of TIM-3, LAG-3, 4-1BB, and PD-i from the bulk population； and (c) separating the cells selected in (b) from unselected cells to obtain a cell population enriched for tumor-reactive T cells are disclosed. Related methods of administering a cell population enriched for tumor-reactive T cells to a mammal, methods of obtaining a pharmaceutical composition comprising a cell population enriched for tumor-reactive T cells, and isolated or purified cell populations are also disclosed.
