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Method for preparing enriched populations of tumor-reactive T cells from peripheral blood
专利权人:
アメリカ合衆国
发明人:
グロス、アレナ,ローゼンバーグ、スティーヴン エイ.,ローゼンバーグ、スティーヴン エイ.
申请号:
JP2015560160
公开号:
JP6257655B2
申请日:
2013.04.30
申请国别(地区):
JP
年份:
2018
代理人:
摘要:
Methods of obtaining a cell population enriched for tumor-reactive T cells, the method comprising: (a) obtaining a bulk population of peripheral blood mononuclear cells (PBMCs) from a sample of peripheral blood; (b) specifically selecting CD8+T cells that also express PD-1 and/or TIM-3 from the bulk population; and (c) separating the cells selected in (b) from unselected cells to obtain a cell population enriched for tumor-reactive T cells are disclosed. Related methods of administering a cell population enriched for tumor-reactive T cells to a mammal, methods of obtaining a pharmaceutical composition comprising a cell population enriched for tumor-reactive T cells, and isolated or purified cell populations are also disclosed.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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