The United States of America; as represented by the Secretary; Department of Health and Human Serv
发明人:
Alena Gros,Steven A. Rosenberg
申请号：
US15813398
公开号：
US20180133253A1
申请日:
2017.11.15
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Methods of obtaining a cell population enriched for tumor-reactive T cells, the method comprising: (a) obtaining a bulk population of peripheral blood mononuclear cells (PBMCs) from a sample of peripheral blood； (b) specifically selecting CD8+ T cells that also express PD-1 and/or TIM-3 from the bulk population； and (c) separating the cells selected in (b) from unselected cells to obtain a cell population enriched for tumor-reactive T cells are disclosed. Related methods of administering a cell population enriched for tumor-reactive T cells to a mammal, methods of obtaining a pharmaceutical composition comprising a cell population enriched for tumor-reactive T cells, and isolated or purified cell populations are also disclosed.
