Wang Shen,Wei Xiao,Jack Maung,Aimin Zhang,Xiaoling Zheng,Zhenzhong Wang,Qingming Guo,Yingguang Li
申请号：
US14118200
公开号：
US09187459B2
申请日:
2012.05.17
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The invention provides quinazoline-7-ether derivatives, particularly 4-anilinyl-6-butenamido-quinazoline-7-ether derivatives that are inhibitors of the receptor protein tyrosine kinases (RTK). The compounds are useful in the treatment of diseases and disorders where RTK activity is implicated such as a hyperproliferative diseases (e.g., cancer). Also provided are methods of preparation of the quinazoline derivatives and methods of use as therapeutic agents alone or in a drug combination.
