FORME CRISTALLISEE I DU DIMALEATE INHIBITEUR DE TYROSINE KINASE ET SES METHODES DE PREPARATION

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专利权人:

JIANGSU HENGRUI MEDICINE CO.; LTD.

发明人:

SUN, PIAOYANG,WU, GUAILI,YUAN, BO,CHEN, YONGJIANG

申请号：

CA2876884

公开号：

CA2876884A1

申请日:

2013.06.04

申请国别(地区):

CA

年份:

2014

代理人:

摘要：

Provided are crystalline Form I of (R,E)-N-(4-(3-chloro-4-(pyridin-2-yl-methoxy)phenylamino)-3-cyano-7- ethoxy-quinolin-6-yl)-3-(1-methyl pyrrolidin-2-yl)propenamide dimaleate (called SHR1258 dimaleate for short), preparation methods thereof and pharmaceutical compositions containing the same. Said crystalline Form I of SHR1258 dimaleate has good crystal stability and chemical stability, and can be used in preparation of medicaments for treating diseases relevant to EGFR receptor tyrosine kinase or HER-2 receptor tyrosine kinase.

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