LEUSEN, JEANNETTE HENRICA WILHELMINA,BOROSS, PETER,JANSEN, JOHANNES HENDRIK MARCO,MEYER, SASKIA
申请号：
CA3035427
公开号：
CA3035427A1
申请日:
2017.09.01
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The invention is related to CD20 antibodies with improved characteristics. Some embodiments describe antibodies comprising a mouse IgG2 a human IgGl, IgAl or IgA2 constant region and a variable domain that can bind the epitope "EPANpSEK" on human CD20 expressed on Ramos cells and which antibody has an increased PCD functionality when compared to Rituximab with a constant region of the same isotype.
