Compounds represented by the formula (I) or pharmaceutically acceptable salts thereof:R 2 -Y-Z-Q-A-R 1Formula (I)wherein R1, R2, Y, Z, Q, and A are as defined. These compounds are inhibitors of tubulin polymerization by binding at colchicines binding site and are useful in the treatment of tumors or mitotic diseases such as cancers, gout, and other conditions associated with abnormal cell proliferation.本發明係關於一新穎微管蛋白抑制劑,其結構如式(I),及其醫藥可接受之鹽類:R 2 -Y-Z-Q-A-R 1式(I)其中該R1、R2、Y、Z、Q及A如申請專利範圍所定義。這些化合物藉由結合於秋水仙鹼結合位置來抑制微管蛋白聚合,且可用於治療腫瘤或有絲分裂等相關疾病,如癌症、痛風及與細胞增殖異常有關的其他疾病。
