KC, SUNIL KUMAR,WALLACE, DAVID MARK,HOOD, JOHN,BARROGA, CHARLENE F.
申请号：
PE0017962015
公开号：
PE17212015A1
申请日:
2014.02.21
申请国别(地区):
PE
年份:
2015
代理人:
摘要：
Refers to the development of analogs of gamma - diketones formula I: which is activating one or more proteins in the Wnt Pathway, useful in the treatment of Parkinsons disease, osteoporosis, etc. in which: the ring is a heteroaryl 7-12 ATOMS, in which a carbon Atom at the ring is Attached to the carbonyl carbon of the phenyl Ring b, etc.R1 is H, alkyl C1 - 6 without replacing, etc. R2 is H, alkyl C1 - 6 without replacing, etc. R3 is H, alkyl C1 - 6 without replacing, etc. r3b is H and alkyl c1-3 without replacing each n is an integer from 1 to 10 and M is an integer from 1 to 5Se refiere al desarrollo de analogos de gamma-dicetonas de Formula I: que es activador de una o mas proteinas en la via Wnt, util en el tratamiento de osteoporosis, enfermedad de Parkinson, etc. en la que: el Anillo A es un heteroarilo de 7-12 atomos, en la que un atomo de carbono en el anillo esta unido al carbono de carbonilo el Anillo B es fenilo, etc. R1 es H, -alquilo C1-6 sin sustituir, etc. R2 es H, -alquilo C1-6 sin sustituir, etc. R3 es H, -alquilo C1-6 sin sustituir, etc. R3b es H y -alquilo C1-3 sin sustituir cada n es un numero entero de 1 a 10 y cada m es un numero entero de 1 a 5
