Compound that acts in multiple receptors for prostaglandins giving a general inflammatory response which is 1 - (5 - [Halo or alkyl or alkoxy - or fluoroalquil 2 - {(cicloalquil or cicloalquil replaced) oxy] phenyl) methyl] - (5 - alkyl or fluoroalquil) - 1H pyrazolo - (or 3 - carboxylic acid carboxy acid Methyl methylene) or an alkyl or aryl sulfonamide or Ester thereof
DAVID F. WOODWARD,WILLIAM R. CARLING,JOSE L. MARTOS,JENNY W. WANG,JUSSI J. KANGASMETSA
申请号：
ARP120104978
公开号：
AR089462A1
申请日:
2012.12.26
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
a. In formula (c8332244), M is 0 or 1 to 3； Z is selected from O, s, so, so, so, so8322y (ch832246)；P is an integer of 0 or 1 to 3； W is the substituted aril, asphalt, substituted asphalt, cyclophylene or cyclophylquile； R1 is selected from or8311；N (r8311d) 83222 and n (r8311811) so8322； r8311；R2 es h； r83088 was selected from the tar, halo tar and ammonia groups； rc830909 was selected from the h, hydroxy, tar, aril, alcoxi, ariloxi, halogen, nitrogen, imine, cyanogen and hydrogen Xi, halogen, nitrogen, amino and cyano tar substitutes, aril, alcoxi or ariloxi groups； r8310 was selected from the group； a. It is composed of H, hydroxy, hydrocarbon, aril, alcox, ariloxi, halogen, nitrogen, ammonia, cyanogen and hydrogen, halogen, nitrogen, amino and cyanogen or substituted tar, aril, alcoxi, which contains at least r83099 and r8310e halogen； r831181 is selected by members of group H；Hydrogenated carbon and hydrogenated carbon The compound plays a role in a number of prostate receptors, providing a general anti-inflammatory response, prior to 1 - [(5-halogenated or tar or fluoropropyl or propyl or propyl-2 - [(cyclopropyl or cyclopropyl substitute) oxygen) phenyl) methyl} (5-tar or fluoropropyl) - 1h-pyrazol-3 - (carboxyl acid or methyl carboxylic acid),Or aril or amine sulfate tar or ester.Un compuesto que se encuentra representado por la fórmula (1) en donde, Y es (CH₂)ₘ en la que m es 0 ó un entero que oscila de 1 a 3； Z es seleccionado a partir del grupo formado por O, S, SO, SO₂ y (CH₂)ₚ, en el que p es 0 ó un entero que oscila de 1 a 3； W es aril sustituido, alquil, alquil sustituido, cicloalquil o cicloalquil sustituido； R¹ se selecciona a partir del grupo formado por OR⁷, N(R⁷)₂ y N(R⁷)SO₂R⁷； R² es H； R⁴ es seleccionado a partir del grupo formado por alquil, halógeno-alquil y amino； R⁵ es seleccionado a partir del grupo formado por H, hidroxil, alquil, aril, alcoxi, ariloxi, halógeno, nitro, amino, ciano e hidroxi, halógeno, nitro, amino y ciano-alquil sustitui
