Derivatives of 1- [7- (cis-4-methyl-cyclohexyloxy) -8-trifluoromethyl-naphthalen-2-ylmethyl] -piperidin-4-carboxylic acid as autotaxin modulators (ATX) to treat inflammation and autoimmune disorders
A compound represented by formula (III): ** (See formula) ** or a pharmaceutically acceptable salt thereof, wherein R3 is hydrogen, a halogen, C1-6 haloalkyl or cyano, provided that when R3 is hydrogen, R1 is a C3-8 cycloalkyl which is optionally substituted with from 1 to 6； R5 is a C1-6 cycloalkylene, C3-8 carbocyclyl, a 3- to 8-membered heterocyclyl, C6-10 aryl, a 5-membered heteroaryl, a bridge-linked ring system comprising 6 to 12 ring members, a spiro ring system comprising 5-14 ring members, or a bicyclic ring system represented by the following formula: ** (See formula) ** in which B 'and B "are independently selected from the group consisting in monocyclic C3-8 carbocyclyl, a monocyclic 3- to 8-membered heterocyclyl, phenyl or a 5- to 6-membered heteroaryl； in which R5 may be optionally substituted with independently selected 1 to 4 R11； R6, for each occurrence, is independently selected from the group consisting of halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, C3-8 cycloalkyl, C6-10 aryl, C1-6 alkoxy-C1-6 alkyl and tri- (C1- alkyl) 6) silyl； or two R6 that are attached to the same carbon atom can form spirocycloal C3-8 alkyl or 3 to 8 membered spiroheterocycloalkyl； R7 is -OH, -C (O) OR15, -C (O) N (R16) 2, -C (O) N (R15) -S (O) 2R15, -S (O) 2OR15, -C (O ) NHC (O) R15, - Si (O) OH, -B (OH) 2, -N (R15) S (O) 2R15, -S (O) 2N (R15) 2, -OP (O) (OR15 ) 2, -P (O) (OR15) 2, -CN, -S (O) 2NHC (O) R15, -C (O) NHS (O) 2R15, -C (O) NHOH, -C (O) NHCN, or a heteroaryl or a heterocyclyl selected from the group consisting of formulas (a) - (i '): ** (See formula) ** R8 and R9 are each independently hydrogen, a carboxy, C1-6 alkyl or a C2-6 alkenyl； or R8 and R9 together with the carbon to which they are attached is -C (>； = O) -, a C3-8 spirocycloalkyl or a 3 to 8 membered spiroheterocycloalkyl； R10 is hydrogen or a C1-6 alkyl； R11, for each occurrence, is independently halogen, hydroxyl, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, - (CR17R18) p-R7, C1-4
