Sean Stevens,Tammy T. Huang,Joel H. Martin,Jeanette L. Fairhurst,Ashique Rafique,Eric Smith,Kevin J. Pobursky,Nicholas J. Papadopoulos,James P. Fandl,Gang Chen,Margaret Karow
申请号：
US15136152
公开号：
US09884916B2
申请日:
2016.04.22
申请国别(地区):
US
年份:
2018
代理人:
摘要：
A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.
