STEVENS, SEAN,CHEN, GANG,KAROW, MARGARET,HUANG, TAMMY T.,MARTIN, JOEL H.,FAIRHURST, JEANETTE L.,RAFIQUE, ASHIQUE,SMITH, ERIC,POBURSKY, KEVIN J.,PAPADOPOULOS, NICHOLAS J.,FANDL, JAMES P.
申请号：
MYPI 20084757
公开号：
MY147468A
申请日:
2007.06.01
申请国别(地区):
MY
年份:
2012
代理人:
摘要：
92 ABSTRACT HIGH AFFINITY ANTIBODIES TO HUMAN II@6 RECEPTOR 5 A HUMAN ANTIBODY OR AN ANTIGEN-BINDING FRAGMENT WHICH BINDS HUMAN IL-6 RECEPTOR (HIL-6R) WITH A KR) OF ABOUT 500 PM OR LESS AND BLOCKS IL-6 ACTIVITY WITH AN IC50 OF 200 PM OR LESS. THE ANTIBODY OR ANTIBODY FRAGMENT BINDS HIL-6R WITH AN AFFINITY AT LEAST 2-FOLD HIGHER RELATIVE TO ITS BINDING TO MONKEY IL-6R.
