FRANK;LIU, SHENGYAN SANDY;GU, FRANK;JONES, LYNDON WILLIAM JAMES;GU
发明人:
GU, FRANK,JONES, LYNDON WILLIAM JAMES,LIU, SHENGYAN SANDY
申请号：
EP13806729
公开号：
EP2863892A4
申请日:
2013.06.20
申请国别(地区):
EP
年份:
2016
代理人:
摘要：
The present disclosure relates generally to a nanoparticle delivery system. The nanoparticles are formed from amphiphilic block copolymers comprising polylactide and dextran. The dextran may be conjugated to a targeting moiety in such a manner that the surface of the nanoparticle is coated with the targeting moiety. The size and targeting of the nanoparticles can be tuned by controlling surface density of the targeting moiety. The present disclosure also relates to polymers and macromolecules useful in the preparation of the mucoadhesive nanoparticles, as well as compositions, methods, commercial packages, kits and uses related thereto.
