Lyndon James William JONES;Shengyan (Sandy) LIU;Frank GU
发明人:
Frank GU,Lyndon James William JONES,Shengyan (Sandy) LIU
申请号：
US14410521
公开号：
US20150320694A1
申请日:
2013.06.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present disclosure relates generally to a mucoadhesive nanoparticle delivery system. The nanoparticles are formed from amphiphilic macromolecules conjugated to a mucosal targeting moiety in such a manner that the surface of the nanoparticle is coated with the targeting moiety. The surface density of the targeting moiety can be tuned for adjustable targeting of the nanoparticles to a mucosal site without substantially compromising the stability of the particles. The particles were found to have high loading efficiency and sustained release properties at the mucosal site. The present disclosure also relates to polymers and macromolecules useful in the preparation of the mucoadhesive nanoparticles, as well as compositions, methods, commercial packages, kits and uses related thereto.
