Steven Do,Richard Goldsmith,Tim Heffron,Aleksandr Kolesnikov,Steven Staben,Alan G. Olivero,Michael Siu,Daniel P. Sutherlin,Bing-Yan Zhu,Paul Goldsmith,Tracy Bayliss,Adrian Folkes,Neil Pegg
申请号：
US14446154
公开号：
US09309265B2
申请日:
2014.07.29
申请国别(地区):
US
年份:
2016
代理人:
摘要：
Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formulas I and II for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
