經由FCγIIB促進抗原消除的抗原結合分子

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专利权人:

CHUGAI SEIYAKU KABUSHIKI KAISHA

发明人:

IGAWA, TOMOYUKI,MAEDA, ATSUHIKO,IWAYANAGI, YUKI,HARAYA, KENTA,KATADA, HITOSHI,KADONO, SHOJIRO,MIMOTO, FUTA,井川智之,前田敦彥,岩柳有起,原谷健太,堅田仁,門野正次郎,味元風太

申请号：

HK15102123.9

公开号：

HK1201476A

申请日:

2015.03.03

申请国别(地区):

HK

年份:

2015

代理人:

摘要：

The present invention provides antigen-binding molecules containing (i) an antigen-binding domain whose antigen-binding activity varies depending on ion concentration conditions, (ii) an Fc³-binding domain having Fc³ RIIb-selective binding activity, and (iii) an FcRn-binding domain having FcRn-binding activity under an acidic pH range condition, and methods of decreasing plasma antigen concentration as compared to before administering the molecule, which include the step of administering the molecule.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/